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Further studies of SJ-172550 using p53-decient(SJmRbl-8) cells and the BJ cells, a human foreskin broblast cell line, as an addi -tional control to estimate general cytotoxicity of the compounds, indicated itsp53-dependent cytotoxicity [59]. At the end of the experiment, theproportion of dead cells was determined by trypan blue exclusion

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At the end of the experiment, theproportion of dead cells was determined by trypan blue exclusion.

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