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Similarly, discontinuation of a CYP3A4 inducer, such as rifampin, carbamazepine, and phenytoin, in hydrocodone bitartrate and acetaminophen oral solution-treated patients may increase hydrocodone plasma concentrations and prolong opioid adverse reactions. When using hydrocodone bitartrate and acetaminophen oral solution with CYP3A4 inhibitors or discontinuing CYP3A4 inducers in hydrocodone bitartrate and acetaminophen oral solution-treated patients, monitor patients closely at frequent intervals and consider dosage reduction of hydrocodone bitartrate and acetaminophen oral solution until stable drug effects are achievedsee PRECAUTIONS; Drug Interactions.A.

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There is one well documented report of rash in a breast-fed infant that resolved when the mother stopped acetaminophen use and recurred when she resumed acetaminophen use. Clinical Considerations If infants are exposed to acetaminophen and codeine what is silapap acetaminophen 160mg 5ml liq tablets through breast milk, they should be monitored for excess sedation and respiratory depression.Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion.

In adults hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams, or fatalities with less than 15 grams.

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Fibromyalgia symptoms include widespread pain, tingling feet or hands, depression, and bowel irritability.Treatment of upper respiratory infections are based upon the cause.

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