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Sertraline
Clinical data
Pronunciation/ ˈ s ə r t r ə ˌ l iː n /
Trade namesZoloft and others [1]
AHFS/Drugs.comMonograph
MedlinePlusa697048
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth (tablets and solution)
Drug classSelective serotonin reuptake inhibitor
ATC codeN06AB06 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability44%
Protein binding98.5%
MetabolismHepatic ( N -demethylation mainly by CYP2B6) [2]
Metabolitesnorsertraline
Elimination half-life~23–26 h (66 h [less-active [3] metabolite, norsertraline]) [4] [5] [6] [7]
ExcretionRenal

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BMed Google Scholar 71Rynn M, Garc a-Espa a F, Greenblatt DJ, et al.Do not drink alcohol while you take ZOLOFT.

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In other published reports, concomitant use of clozapine and SSRIs fluvoxamine, paroxetine, sertraline resulted in modest increases less than twofold in clozapine and metabolite does zoloft help with anxiety and panic attacks. The manufacturer of clozapine states that caution should be exercised and patients closely monitored if clozapine is used in patients receiving SSRIs, and a reduction in clozapine dosage should be considered.Efficacy and tolerability of antidepressants in pediatric anxiety disorders: A systematic review and meta-analysis.

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Abnormal vision including blurred vision occurred in about 4% of patients receiving sertraline in controlled clinical trials. Adverse ocular effects reported in 0.Adverse reactions that do not appear in Table 3 most common adverse reactions in adults yet were reported in at least 2% of pediatric patients and at a rate of at least twice the placebo rate include fever, hyperkinesia, urinary incontinence, aggression, epistaxis, purpura, arthralgia, decreased weight, muscle twitching, and anxiety.

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Use the dropper provided to remove the required amount of Zoloft oral solution and mix with 4 ounces 1/2 cup of water, ginger ale, lemon/lime soda, lemonade or orange juice ONLY.Available studies evaluating teratogenic effects following maternal use of sertraline in the first trimester have not shown an overall increased risk of major birth defects. Studies evaluating specific birth defects have provided inconsistent results.

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Antidepressant-associated bruxism may occur in pediatric and adult patients, most commonly among female patients.In addition, monitor for signs and symptoms of bleeding.

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Ertraline belongs to a class of drugs called selective doe zoloft help panic attacks reuptake inhibitors SSRIs Other drugs in this class are: luoxetine Prozac, Sarafem aroxetine Brisdelle, Paxil, Paxil CR, Pexeva italopram Celexa luvoxamine Luvox CR Fluoxetine is available as capsules: 10, 20 and 40 mg.NauseaLoss of appetite, iarrheaIndigestionIncreased sweating hyperhidrosis remor or shakingAgitationChange in sleep habits including increased sleepiness or insomniaSexual problems including decreased libido and ejaculation dysfunctionFeeling tired or fatiguedAnxiety Do not stop sertraline without first talking to your healthcare provider.

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Treatment with sertraline should not be initiated in a patient receiving linezolid; when necessary, sertraline may be started 24 hours after the last linezolid dose.Patients receiving warfarintherapy should be carefully monitored when ZOLOFT is initiated or discontinued - see PRECAUTIONS, bnormal Bleeding Alteredanticoagulant effects, including increased bleeding, have been reported whenSSRIs or SNRIs are coadministered with warfarin.

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